A plasmacytoid dendritic cell (CD123+/CD11c−) based assay system to predict contact allergenicity of chemicals

Blastic Plasmacytoid Dendritic Cell Neoplasm; A Report of Three Cases

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematodermic myeloid malignancy that is known to be derived from plasmacytoid dendritic cells which are characterized by expression of CD4, CD56, and more specific markers such as CD123. Here, the authors present three cases of BPDCN diagnosed in the past two years and address different available diagnostic modalities such as morpho...

Constitutive Plasmacytoid Dendritic Cell

Blastic Plasmacytoid Dendritic Cell Neoplasm

Introduction Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, highly aggressive hematopoietic malignancy. It manifests as cutaneous and bone marrow involvement and leukemic spread. It represents 0.7% of primary cutaneous lymphomas. Recently, it was established as a distinct entity. We present a rare case of BPDCN with good response to chemotherapy and review the clinicopathologic...

Blastic plasmacytoid dendritic cell neoplasms

1Department of Hematology, Medical University of Łódź Head of Department: prof. Tadeusz Robak, MD, PhD 2Department of Experimental Hematology, Medical University of Łódź Head of Department: prof. Piotr Smolewski, MD, PhD 3Department of Pathology, Medical University of Łódź Head of Department: prof. Radzisław Kordek, MD, PhD 4Department of Cytogenetic, The Maria Skłodowska-Curie Memorial Cancer ...

Plasmacytoid dendritic cells regulate autoreactive B cell activation via soluble factors and in a cell-to-cell contact manner.

Plasmacytoid dendritic cells (pDCs) are specialized type I IFN producers, which play an important role in pathogenesis of autoimmune disorders. Dysregulated autoreactive B cell activation is a hallmark in most autoimmune diseases. This study was undertaken to investigate interactions between pDCs and autoreactive B cells. After coculture of autoreactive B cells that recognize self-Ag small nucl...